Metagenomics for chronic meningitis: clarifying interpretation and diagnosis
M. R. Wilson, B. D. O'Donovan, J. M. Gelfand, H. A. Sample, F. C. Chow, J. P. Betjemann, M. P. Shah, M. B. Richie, M. P. Gorman, R. A. Hajj-Ali, L. H. Calabrese, K. C. Zorn, J. E. Greenlee, J. H. Blum, G. Green, , J. L. DeRisi
This study uses metagenomic next-generation sequencing of cerebrospinal fluid to identify pathogens in patients with subacute or chronic meningitis, using a z-score based scoring algorithm to distinguish true pathogens from environmental contaminants.
bioRxiv · Nov 7, 2017Microbiology