M. R. Wilson

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities

This paper validates a murine proteome-wide PhIP-seq library to identify autoantibody specificities in autoimmune disease models.

Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq

This paper scales PhIP-Seq for autoantibody discovery across multiple autoimmune diseases and COVID19, enabling machine learning predictions and identification of disease-specific autoantigens.

Elevated N-glycosylation of immunoglobulin G variable regions in myasthenia gravis highlights a commonality across autoantibody-associated diseases

This study identifies elevated N-glycosylation in IgG variable regions in myasthenia gravis patients and shows it is not required for autoantigen binding.

Exercise training in a color-polymorphic lizard reveals differential effects of mating tactics and color morphs on telomere, body condition and growth dynamics

The paper examines how exercise affects telomere dynamics, body condition, and growth in color-polymorphic lizards, finding differential impacts based on mating tactics and color morphs.

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

The reactivity of an unusual amidase may explain colibactin’s DNA cross-linking activity

This paper identifies ClbL as an amidase enzyme that forms amide bonds, contributing to colibactin's DNA cross-linking activity by incorporating electrophilic warheads into its structure.

In vitro characterization of the colibactin-activating peptidase ClbP enables development of a fluorogenic activity probe

This study characterizes the in vitro activity of ClbP, a peptidase involved in colibactin biosynthesis, and develops a fluorogenic probe to detect its activity.

Exploration of Anti-Yo and Anti-Hu paraneoplastic neurological disorders by PhIP-Seq reveals a highly restricted pattern of antibody epitopes

This study uses PhIP-Seq to identify epitopes of anti-Yo and anti-Hu autoantibodies in PND patients, revealing restricted antigenic patterns and potential biomarkers.

Longitudinally persistent cerebrospinal fluid B-cells resist treatment in multiple sclerosis

This study identifies persistent B-cell clones in the cerebrospinal fluid of MS patients despite treatment, suggesting therapy-resistant immune mechanisms in the central nervous system.

Metagenomics for chronic meningitis: clarifying interpretation and diagnosis

This study uses metagenomic next-generation sequencing of cerebrospinal fluid to identify pathogens in patients with subacute or chronic meningitis, using a z-score based scoring algorithm to distinguish true pathogens from environmental contaminants.