Qualitative and Quantitative Concentration-Response Modelling of Gene Co-expression Networks to Unlock Hepatotoxic Mechanisms for Next Generation Chemical Safety Assessment
S. J. Kunnen, E. Arnesdotter, C. T. Willenbockel, M. Vinken, B. van de Water
This study uses concentration-response modelling of gene co-expression networks in human hepatocyte cultures to identify transcriptomics points of departure for hepatotoxicity, aiding in chemical safety assessment.
bioRxiv · Feb 1, 2023Pharmacology & Toxicology