Cancer Cell Line Heterogeneity Imposes a Primary Bottleneck for Virtual Perturbation Screening at Scale
Kai-rui Wei, Li-jing Zhan, Can-Yang Qi
The paper extends a perturbation prediction model to 162 cancer cell lines and finds cancer cell line heterogeneity significantly reduces prediction accuracy compared to normal and primary cell lines.
bioRxiv · Aug 18, 2026 · PreprintBioinformatics