Natural Variation in HIV-1 Entry Kinetics Map to Specific Residues and Reveal an Interdependence Between Attachment and Fusion
Nicholas E. Webb, Colin Sevareid, Carolina Sanchez, Nicole H. Tobin, Grace M. Aldrovandi
The paper analyzes HIV-1 entry kinetics across 257 isolates, identifying single-residue determinants and showing cooperative sequential roles of co-receptor engagement and gp41 function in entry.
bioRxiv · Jun 25, 2024 · PreprintMolecular Biology