Epigenetically silenced DACT3 promotes tumor growth via affecting Wnt/beta-catenin signaling and supports chidamide plus azacitidine therapy in acute myeloid leukemia
Duanfeng Jiang, Qiuyu Mo, Haigang Shao, Jie Meng, Ruilan Zhong, Xunxiu Ji, Changjiu Liang, Wen‐Yuan Lin, Fangping Chen, Min Dong
This study identifies DACT3 as an epigenetically silenced tumor suppressor in AML, showing its role in Wnt signaling and potential as a therapeutic target when combined with DNMT and HDAC inhibitors.
bioRxiv · Jan 9, 2023 · PreprintMolecular Biology