ICONIC: An R Package for Integrating Instrumental Variable- and Negative-Control-Informed Causal Discovery and Diagnostics in Multiomic Studies
Sean T. Bresnahan, Charis Xiong, S. Taylor Head, Yung-Han Chang, Arjun Bhattacharya, Jonathan Yinhao Huang
ICONIC is an R package that integrates instrumental variable and negative-control methods for causal inference in multi-omic studies, offering diagnostics and benchmarks for mediation analysis.
medRxiv · Aug 31, 2026 · PreprintGenetic & Genomic Medicine