High Purity Differential Expression of Genes across Spatial Domains
Bingbo Wang, Chenxi Guo, Jiaojiao He, Lin Gao
The paper identifies and validates High-Purity Differential Expression (HiP-DEP) in spatial domains, showing it is more prevalent than bulk or single-cell data and applies it to cancer, Alzheimer's, and brain tissue analysis.
bioRxiv · Apr 23, 2026 · PreprintBioinformatics