Ultrarare Variants in Genes Involved in Intestinal Microbiota and Permeability Homeostasis in Youth with Developmental and Neuropsychiatric Deteriorations
Jennifer Frankovich, Robert Dubin, Chetna Natarajan, Noelle Schlenk, Erika Pedrosa, Erin Stolte, Nicole Rice, Anjana Soorajkumar, Dhanya Vettiatil, Peter J. van der Spek, Janet L. Cunningham, Herbert M. Lachman
The paper identifies ultrarare genetic variants in intestinal homeostasis genes in youth with neuropsychiatric deteriorations and gastrointestinal symptoms, suggesting a potential link to disease pathogenesis.
medRxiv · May 30, 2026 · PreprintGenetic & Genomic Medicine