Direct high-throughput deconvolution of non-canonical bases via nanopore sequencing and bootstrapped learning
Mauricio Pérez, Michiko Kimoto, Priscilla D. Rajakumar, Chayaporn Suphavilai, Rafael Peres da Silva, Hui Pen Tan, Nicholas Ting Xun Ong, Hannah Nicholas, Ichiro Hirao, Chew Wei Leong, Niranjan Nagarajan
This paper demonstrates direct high-throughput sequencing of non-canonical bases using nanopore sequencing and bootstrapped learning, achieving high accuracy and specificity in basecalling.
bioRxiv · Dec 2, 2024 · PreprintSynthetic Biology