Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66-independent targeting of NogoA
Cheng‐Yung Lin, Chia Lun Wu, Kok Zhi Lee, You Jei Chen, Po Hsiang Zhang, Chia‐Yu Chang, Horng Jyh Harn, Shinn Zong Lin, Huai‐Jen Tsai
The paper shows that extracellular Pgk1 promotes motoneuron outgrowth by inhibiting a signaling pathway, independent of Nogo66, and rescues denervation in zebrafish and ALS mouse models.
eLife · Jul 30, 2019Peer-reviewedDevelopmental Biology