An arginine switch drives the stepwise activation of β-arrestin
Jeong Seok Ji, Yaejin Yun, Tomasz Maciej Stępniewski, Hye‐Jin Yoon, Kyung-Jin Min, Ji Young Park, Chiwoon Chung, Ka Young Chung, Jana Selent, Hyung Ho Lee
This study identifies an arginine switch mechanism that drives the stepwise activation of β-arrestin through conformational changes induced by GPCR interactions.
bioRxiv · Jan 5, 2025 · PreprintBiochemistry