Author

Christian J. Steinmetz

Harvard University

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Biology Disciplines

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Genomics· 1

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Assay:DNA methylation· 1 Organism:multiple species· 1 Approach:transformer / foundation model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

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Artem GazizoviD· 1 shared Aviv SpinneriD· 1 shared Courtney A. SheareriD· 1 shared Daniel RitteriD· 1 shared Debora S. MarksiD· 1 shared Erik XieiD· 1 shared Felix TeufeliD· 1 shared Jonathan FrazeriD· 1 shared

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1 shared paperGenomics

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1 paper

Recent·Most cited

GenomicsbioRxivPreprintNov 11, 2024

A Genomic Language Model for Zero-Shot Prediction of PromoterVariant Effects

Courtney A. Shearer, Rose Orenbuch, Felix Teufel…·Debora S. Marks

LOL-EVE predicts promoter variant effects using a transformer model trained on mammalian promoter sequences, showing improved performance in indel prediction and haplotype analysis.

2 citations

multiple speciesDNA methylation

𝕏 PostBluesky