Structural insights into the opening mechanism of C1C2 channelrhodopsin
Matthias Mulder, Songhwan Hwang, Matthias Broser, Steffen Brünle, Petr Skopintsev, Caspar Jonas Schattenberg, Christina Schnick, Sina Hartmann, Jonathan Richard Church, Igor Schapiro, Florian Dworkowski, Tobias Weinert, Peter Hegemann, Han Sun, Jörg Standfuss
This study uses time-resolved crystallography and MD simulations to reveal structural changes in C1C2 channelrhodopsin during activation, showing how conformational shifts enable ion conduction.
Journal of the American Chemical Society · Dec 16, 2024Peer-reviewedBiophysics