Agent-Guided De Novo Design of Nanobody Binders Against a Novel Cancer Target
Yue Zhao, Melih Yilmaz, Edward Lee, Chuanyui Teh, Lan Shen Guo, Kemal Sönmez, Luca Giancardo, Gordon Trang, Fangda Xu, Madelyn M. Espinosa-Cotton, Nai‐Kong V. Cheung, Jiwon Kim, Xinyun Cheng
The paper presents a computational workflow for designing nanobody binders against a novel cancer target, achieving sub-nanomolar affinities without experimental structure or prior antibody data.
bioRxiv · Apr 17, 2026 · PreprintBioinformatics