Single-cell RNA sequencing of Tocilizumab-treated peripheral blood mononuclear cells as an in vitro model of inflammation
Arya Zarinsefat, George C. Hartoularos, Dmitry Rychkov, Priyanka Rashmi, Sindhu Chandran, Flavio G. Vincenti, Chun J. Yee, Minnie Sarwal
This study uses single-cell RNA sequencing to analyze Tocilizumab-treated PBMCs, showing reduced inflammatory gene expression in monocytes, supporting its potential to mitigate cytokine storms in COVID-19.
Frontiers in Genetics · Jan 5, 2021Peer-reviewedGenomics