eIF2Bϵ phosphorylation activates integrated stress response-mediated protein translation and links stress signalling toamyloidogenesis in Alzheimer's disease
Hugo Fanlo-Ucar, Clara Planas-Clopes, Oriol Bagudanch, Carlos Pardo, Scarlett Troncoso-Cotal, Alejandra R. Alvarez, Baldomero Oliva, Francisco J. Muñoz
This study identifies a novel GSK-3β-eIF2Bε-BACE1 axis that links stress response dysregulation to amyloidogenesis in Alzheimer's disease, independent of canonical eIF2 phosphorylation.
bioRxiv · Nov 3, 2025 · PreprintNeuroscience