Substrate-dependent epistasis probes active site intramolecular wiring
Karol Buda, Charlotte M. Miton, Clara Vogt, Nobuhiko Tokuriki
This study maps substrate-dependent epistasis in phosphotriesterase by analyzing 64 mutation combinations across nine substrates, revealing how intramolecular wiring changes to support promiscuity and functional trade-offs.
bioRxiv · Jul 3, 2026 · PreprintBiochemistry