Systemic mutagen exposures reported by normal kidney cell genomes
Yichen Wang, W. Knight, Aida Ferreiro-Iglesias, Behnoush Abedi‐Ardekani, My H. Pham, Sarah Moody, Yvette E. Hooks, Federico Abascal, Charles Nunn, Stephen F. Fitzgerald, Thomas Cattiaux, Valérie Gaborieau, Akihiko Fukagawa, Viorel Jinga, Ștefan Rașcu, , Michael R. Stratton
The paper identifies mutational signatures in normal kidney cells from multiple countries, revealing exposure to exogenous mutagens including aristolochic acids and unknown agents prevalent in Japan.
bioRxiv · Apr 9, 2026 · PreprintGenomics