Promiscuous esterases counterintuitively are less flexible than specific ones
C. Nutschel, C. Coscolin, D. Mulnaes, B. David, M. Ferrer, K.-E. Jaeger, H. Gohlke
The paper shows that promiscuous esterases are less flexible and more thermostable than specific ones, challenging the common assumption about enzyme flexibility and promiscuity.
Journal of Chemical Information and Modeling · May 24, 2021Peer-reviewedBiophysics