Computational Analysis of Protein Stability and Allosteric Interaction Networks in Distinct Conformational Forms of the SARS-CoV-2 Spike D614G Mutant: Reconciling Functional Mechanisms through Allosteric Model of Spike Regulation
G. Verkhivker, S. Agajanian, D. Oztas, G. Gupta
This study uses computational methods to analyze how the D614G mutation in SARS-CoV-2 spike protein affects stability and allosteric communication, showing it enhances infectivity through structural changes.
bioRxiv · Jan 26, 2021Biophysics