Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes
N. Adler, A. T. Bahcheli, K. Cheng, K. N. Al-Zahrani, M. Slobodyanyuk, D. Pellegrina, D. Schramek, J. Reimand
The paper analyzes the impact of mutational signatures from tobacco smoking and APOBEC activity on protein-truncating mutations in 12,341 cancer genomes across 18 types, showing their enrichment in key cancer pathways and tumor suppressors.
bioRxiv · Mar 19, 2023Cancer Biology