Mammalian mitochondrial mutational spectrum as a hallmark of cellular and organismal aging.
A. G. Mikhaylova, A. A. Mikhailova, K. Ushakova, E.O. Tretiakov, V. Shamansky, Andrey A. Yurchenko, M. Zazhytska, E. Zdobnov, Vsevolod J. Makeev, Valerian A. Yurov, M. Tanaka, Irina S. Gostimskaya, Z. Fleischmann, S. Annis, M. Franco, , K. Popadin
The paper investigates mtDNA mutational spectra across species and tissues, finding a correlation between AH>GH substitutions and longevity, suggesting it as a potential oxidative damage signature in mtDNA.
bioRxiv · Apr 27, 2021 · PreprintGenomics