Alina G. Mikhailova

Mitochondrial Deletions and Healthspan: Lessons from the Common Repeat

The paper investigates the role of mitochondrial DNA repeats in aging and healthspan, finding that disrupting the common repeat reduces somatic deletions and improves healthspan.

Mitochondrial mutation spectrum in Chordates: damage versus replication signatures, causes, and dynamics

The paper analyzes the mitochondrial mutation spectrum in chordates, identifying three main mutation signatures and their underlying causes, with implications for age-related disease prevention.

Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome

The paper identifies a contact zone in the human mitochondrial genome where deletions are more likely, linking it to aging and lifespan.

A mitochondria-specific mutational signature of aging: increased rate of A>G substitutions on a heavy chain.

The paper identifies an AH>GH substitution signature in mtDNA linked to aging and TSSS, showing higher frequency in species with longer generation lengths.

Mammalian mitochondrial mutational spectrum as a hallmark of cellular and organismal aging.

The paper investigates mtDNA mutational spectra across species and tissues, finding a correlation between AH>GH substitutions and longevity, suggesting it as a potential oxidative damage signature in mtDNA.