Author

Dan T.S. Pike

University of Bristol

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

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Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:diffusion model· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Adrian John MulhollandiD· 2 shared A. Sofia F. OliveiraiD· 1 shared Balazs BalegaiD· 1 shared Erica J. PrenticeiD· 1 shared JAMES M. SPENCERiD· 1 shared Marc W. van der KampiD· 1 shared Michael BeeriD· 1 shared Swati SinghiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Adrian John MulhollandORCID

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2 papers

Recent·Most cited

Correlated dynamics, reactive conformations and non-Arrhenius behaviour in the temperature-dependence of enzyme activity: triosephosphate isomerase

Dan T.S. Pike, Swati Singh, Erica J. Prentice, Tom A. Williams, Marc W. van der Kamp, Vickery L. Arcus, Adrian John Mulholland

This study investigates the temperature dependence of triosephosphate isomerase activity using experiments and simulations, revealing non-Arrhenius behavior and dynamical differences between enzymes from different organisms.

bioRxiv · Dec 31, 2025 · PreprintBiochemistry

A dynamical-nonequilibrium molecular dynamics (D-NEMD) alanine scanning approach for identifying allosteric positions in proteins

Balazs Balega, Michael Beer, Dan T.S. Pike, JAMES M. SPENCER, A. Sofia F. Oliveira, Adrian John Mulholland

This paper introduces a D-NEMD method to identify allosteric positions in proteins by analyzing long-range structural responses to alanine substitutions, validated on KPC-2 beta-lactamase.

bioRxiv · Nov 29, 2025 · PreprintBiochemistry