The usage of human IGHJ genes follows a particular nonrandom selection: The recombination signal sequence affects the usage of human IGHJ genes
Bin Shi, Xiaoheng Dong, Ma Qingqing, Suhong Sun, Long Ma, Jiang Yu, Xiaomei Wang, Juan Pan, Xiaoyan He, Danhua Su, Xinsheng Yao
The paper analyzes IGHJ gene usage in BCR repertoires and finds that recombination signal sequences influence their frequencies across physiological and pathological conditions.
Frontiers in Genetics · Dec 8, 2020Peer-reviewedGenomics