The Causal Pivot: A Structural Approach to Genetic Heterogeneity and Variant Discovery in Complex Diseases
Chad A. Shaw, C.J. Williams, Taotao Tan, Daniel Illera, Na Di, Joshua M Shulman, John W. Belmont
The paper introduces the Causal Pivot (CP) method to detect causal genetic variants in complex diseases using structural causal models and applies it to UK Biobank data for three diseases.
The American Journal of Human Genetics · Aug 18, 2025Peer-reviewedGenetics