Author

Daniel Macías

Consejo Superior de Investigaciones Científicas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Assay:bulk RNA-seq· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:fine-mapping· 1 Assay:GWAS summary statistics· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Andrew SingletoniD· 3 shared Astrid Daniela Adarmes-GómeziD· 3 shared Carlota Méndez‐del‐BarrioiD· 3 shared Ciara García· 3 shared Cornelis BlauwendraatiD· 3 shared Cristina Tejera‐ParradoiD· 3 shared Dena G. HernandeziD· 3 shared Dolores Buiza‐RuedaiD· 3 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioinformatics

Andrew SingletonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Regulatory sites for known and novel splicing in human basal ganglia are enriched for disease-relevant information

Sebastian Guelfi, Karishma D’Sa, Juan Antonio Botía, Jana Vandrovcová, Regina Hertfelder Reynolds, David Zhang, Daniah Trabzuni, Leonardo Collado‐Torres, Andrew Thomason, Pedro Quijada Leyton, Sarah A. Gagliano Taliun, Mike A. Nalls, Alastair John Noyce, Aude Nicolas, Mark Cookson, , Elisabet Mondragón Rezola

The paper identifies disease-relevant regulatory loci in human basal ganglia using genomic and transcriptomic data from 117 brains, highlighting splicing eQTLs and ASE analyses as sources of cell-specific regulatory information.

Nature Communications · Feb 25, 2020Peer-reviewedBioinformatics

The genetic architecture of Parkinson disease in Spain: characterizing population-specific risk, differential haplotype structures, and providing etiologic insight

Sara Bandrés‐Ciga, Sarah Ahmed, Marya S. Sabir, Cornelis Blauwendraat, Astrid Daniela Adarmes-Gómez, Inmaculada Bernal‐Bernal, Marta Bonilla‐Toribio, Dolores Buiza‐Rueda, Fátima Carrillo, Mario Carrión‐Claro, Pilar Gómez‐Garre, Silvia Jesús, Miguel Ángel Labrador‐Espinosa, Daniel Macías, Carlota Méndez‐del‐Barrio, , Andrew Singleton

This study conducts a GWAS of Parkinson disease in Spain, identifies a novel population-specific signal at PARK2 associated with age-at-onset, and highlights genetic substructure for future fine-mapping.

Movement Disorders · Oct 29, 2019Peer-reviewedNeuroscience

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

Regina Hertfelder Reynolds, Juan Antonio Botía, Mike A. Nalls, Alastair John Noyce, Aude Nicolas, Mark Cookson, Sara Bandrés‐Ciga, Jesse Raphael Gibbs, Dena G. Hernandez, Andrew Singleton, Xylena Reed, Hampton L. Leonard, Cornelis Blauwendraat, Faraz Faghri, José Brás, , Oriol Dols‐Icardo

This study connects Parkinson’s disease heritability to cell-type-specific gene regulation, finding enrichment in lysosomal genes in astrocytic and microglial subtypes rather than specific cell types or brain regions.

npj Parkinson s Disease · Apr 17, 2019Peer-reviewedGenomics