Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy
Peipei Pan, Daniel J. Weisenberger, Siyu Zheng, Marie Wolf, David G. Hwang, Jennifer Rose‐Nussbaumer, Ula V. Jurkunas, Matilda Frances Chan
The paper identifies aberrant DNA methylation of miRNA genes, particularly miR-199B, in Fuchs endothelial corneal dystrophy, linking it to dysregulated extracellular matrix production through miR-199b-5p suppression of Snai1 and ZEB1.
Scientific Reports · Nov 8, 2019Peer-reviewedGenetics