Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data
Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David Nusinow, Kaitlin E. Samocha, Anne O'Donnell Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier, Shamil R. Sunyaev
The paper estimates genome-wide selection coefficients for heterozygous protein truncating variants using exome data from 60,706 individuals and identifies genes under strong selection.
bioRxiv · Sep 16, 2016Genomics