Transcription factors overcome the repressive impact of Polycomb-associated methylation in tumors
Min-Kyeong Kwon, Goeun Park, Dayoung Go, Donghyun Park, Sridhar S. Hannenhalli, Sun Shim Choi
The paper maps promoter methylation and gene expression changes in colorectal cancer, showing that Polycomb-associated promoters resist methylation-driven repression, particularly for transcription factor genes.
bioRxiv · May 15, 2025 · PreprintBioinformatics