Toward a digital twin for Enterococcus faecium: An experimentally validated manually curated genome-scale metabolic model of strain TX0016 reproduces high-throughput phenotyping data
Dina Samir Rasmi, Jayanth Krishnan, Yomna A. Hashem, Bernhard Ørn Palsson, Mona T. Kashef, Jonathan M. Monk, Ramy Karam Aziz
The paper constructs a genome-scale metabolic model for E. faecium TX0016 that accurately predicts auxotrophies and carbon source utilization, and compares its gene essentiality predictions to E. faecalis data.
bioRxiv · Sep 22, 2026 · PreprintSystems Biology