Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
Mikhail V Pogorelyy, Yuval Elhanati, Quentin Marcou, Anastasia L Sycheva, Ekaterina A Komech, Vadim I Nazarov, Olga V Britanova, Dmitriy M Chudakov, Ilgar Z Mamedov, Yuri B Lebedev, Thierry Mora, Aleksandra M Walczak
The paper shows that fetal T-cell receptor clones persist into adulthood, contributing to the public TCR repertoire and decaying slowly with age.
bioRxiv · Feb 9, 2016Immunology