Enhancing the Reverse Transcriptase Function in Taq Polymerase via AI-driven Multiparametric Rational Design
Yulia E. Tomilova, Nikolay Russkikh, Igor M. Yi, Elizaveta V. Shaburova, Viktor N. Tomilov, Galina B. Pyrinova, Svetlana O. Brezhneva, Olga S. Tikhonyuk, Nadezhda S. Gololobova, Dmitriy V. Popichenko, Maxim O. Arkhipov, Leonid O. Bryzgalov, E. V. Brenner, Anastasia A. Artyukh, Dmitry N. Shtokalo, , Mikhail Ivanov
This paper uses AI-driven rational design and wet-lab analysis to create Taq polymerase mutants with enhanced reverse transcriptase activity while maintaining other key properties.
Frontiers in Bioengineering and Biotechnology · Dec 9, 2024Peer-reviewedBioengineering