The YTHDC1 glutamate-rich domain docks to the ADAR1 Zα Domain, linking the N6-methyladenosine modification of pre-mRNAs to dsRNA editing
Dmitry Gromak, Alexey К. Shaytan, Alan G. Herbert, Maria S. Poptsova
The paper uses AI-driven protein design to discover that ADAR1 interacts with YTHDC1, linking m6A modification to dsRNA editing and suggesting a mechanism for RNA editing regulation.
bioRxiv · Jul 12, 2026 · PreprintBioinformatics