Pain-regulation circuitry as a predictor of chronic pain phenotypes
Alireza Aleali, Muhammad Alı Hashmı, Alon Friedman, Ian Beaupre, Douglas B. Cane, Javeria Ali Hashmi
The paper identifies high and low PDA groups in chronic pain patients using clustering and shows differences in pain modulation, PAG connectivity, and behavioral markers, with machine learning models achieving above-chance classification.
bioRxiv · Jan 21, 2026 · PreprintNeuroscience