pLM representations unlock metagenomic space beyond homology
Lola Le Breton, David Heurtel-Depeiges, Douglas C. Millar, Lara E. Zetzsche, Robert McCoy Vernon, CHRISTOPHER JAMES LANGMEAD, Sarath Chandar, Quentin Fournier
This paper shows that protein language models can better annotate metagenomic proteins when trained on curated data, enabling retrieval of diverse enzyme candidates from billions of sequences.
bioRxiv · Jul 30, 2026 · PreprintBioinformatics