A Cluster-Specific First-principles Network Pharmacology Framework for Molecular-Level Mechanism Deduction: Application to the HL-60-Selective Cytotoxicity of 3-Deoxycardiobutanolide
T. Dung Dang, Viet H. Pham, Ngan T. T. Nguyen, Phong X. Nguyen, Duc M. Trinh
This paper introduces a network pharmacology framework to generate molecular-level hypotheses for drug mechanisms, applying it to explain the selective cytotoxicity of 3-deoxycardiobutanolide in HL-60 cells.
bioRxiv · Aug 6, 2026 · PreprintBioinformatics