Effect of Glycosylation on the Free Energy Landscape of the Catalytic Domain of Human Carbonic Anhydrase IX
Ritwika Dey, Dulal Mondal, Debayan Chakraborty, Srabani Taraphder
This study uses molecular dynamics simulations to analyze how glycosylation affects the free energy landscape of HCA IX's catalytic domain in monomeric and dimeric forms, revealing increased landscape complexity with glycosylation.
bioRxiv · Aug 26, 2026 · PreprintBiophysics