Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor
E. Brintnell, M. Gupta, D. W. Anderson
The paper uses phylogenetic analysis and simulations to show that the common ancestor of SARS-CoV-2 and RaTG13 had high ACE2 binding affinity, suggesting latent human infectivity potential.
bioRxiv · Jun 22, 2020 · PreprintEvolutionary Biology