Comparative Study of State-Dependent Cholesterol Binding Sites in Adenosine A2A and A1 Receptors Using Coarse-Grained Molecular Dynamics Simulations in Biologically Relevant Membranes
E. Tzortzini, R. A. Corey, A. Kolocouris
This study uses CG MD simulations to compare cholesterol binding sites in active and inactive states of A2A and A1 adenosine receptors, identifying differences in binding stability and residence times.
bioRxiv · Sep 28, 2022 · PreprintBiophysics