Classification of Human Transcription Factors Based on Their Effector Domains via Unsupervised Learning
Eduardo A. Ayala, Ayush Gupta, Nehil Shreyash, Arvind Ramanathan, Gül H. Zerze
The paper classifies human transcription factors based on effector domain sequences using unsupervised learning and identifies features correlating with transcriptional activity and co-evolution with DNA-binding domains.
bioRxiv · Oct 26, 2025 · PreprintBioinformatics