Buffet-Style Expression Factor-Adjusted Discovery Increases the Yield of Robust Expression Quantitative Trait Loci
Peter Castaldi, Ma’en Obeidat, Eitan Halper-Stromberg, Andrew Lamb, Margaret Parker, Robert Chase, Vincent Carey, Ruth Tal-Singer, Edwin Silverman, Don Sin, Peter D Paré, Craig Hersh
The paper shows that adjusting for expression factors reduces eQTL detection but proposes a buffet-style approach to balance power and accuracy.
bioRxiv · Oct 11, 2015 · PreprintGenomics