The fitness cost of a congenital heart defect shapes its genetic architecture
Ehiole Akhirome, Suk D. Regmi, Rachel A. Magnan, Nelson Ugwu, Yidan Qin, Claire E. Schulkey, James M. Cheverud, Patrick Y. Jay
This study investigates how the fitness cost of congenital heart defects influences their genetic architecture using a mouse model, finding that epistasis and genetic compatibility play significant roles in risk.
bioRxiv · Feb 2, 2019 · PreprintGenetics