Composite Biofidelity: Addressing Metric Degeneracy in Biomechanical Model Validation and Machine Learning Loss Design
Amruta Koshe, Ehsan Sobhani-Tehrani, Kian Jalaleddini, Hamid Motallebzadeh
The paper develops a multi-metric framework to assess spectral biofidelity, showing that no single metric reliably captures all types of spectral distortion and that consensus across metrics improves validation and machine learning loss design.
bioRxiv · Apr 8, 2026 · PreprintBioengineering