Elamathi Natarajan

Integrated 16S rRNA Bioinformatics Analysis of Gut Microbiota, Predicted Pathways, and Candidate Biomarkers in Inflammatory Bowel Disease

This study analyzes gut microbiota and predicted functions in IBD patients and healthy controls, identifying microbial signatures and pathway associations.

Cross-Dataset Reanalysis of Mouse Alzheimer Disease Single-Cell RNA-Sequencing Data Reveals a Reproducible Innate Immune Activation Signature

The paper reanalyzes six mouse AD scRNA-seq datasets to identify a reproducible innate immune activation signature across studies.

Deciphering the Tumor Microenvironment: An Integrated Single-Cell RNA-Seq and AI Framework for Novel Biomarker and Therapeutic Target Discovery in Melanoma

This paper develops an AI framework integrating single-cell RNA-seq and machine learning to analyze melanoma tumor microenvironment heterogeneity, identifying biomarkers and therapeutic targets.

Integrated Multi-Omics Analysis for the Identification of Disease-Associated Variations and Prognostic Biomarkers in Triple-Negative Breast Cancer (TNBC)

The paper develops a 15-gene prognostic signature and nomogram for TNBC using multi-omic data integration and machine learning, showing strong prognostic separation and external validation.

Graph Neural Networks (GNNs) for Protein-Ligand Interaction Prediction

This paper explores the use of Graph Neural Networks for predicting protein-ligand interactions, focusing on improving interpretability and accuracy through various techniques.

NETWORK-BASED FUNCTIONAL FRAGILITY REVEALS SYSTEM-LEVEL REORGANIZATION OF THE GUT MICROBIOME IN INFLAMMATORY BOWEL DISEASE

This study uses network analysis to show that IBD alters gut microbiome functional organization, leading to fragmented and fragile networks compared to healthy controls.

Identification and Analysis of Novel RNA Editing Sites in Neurodegenerative Diseases Using Machine Learning Approaches.

This paper identifies novel A-to-I RNA editing sites in Alzheimer's disease using machine learning and finds they are enriched in exons and associated with neurodegeneration pathways.