Loss of CFHR5 function reduces the risk for age-related macular degeneration
Mary Pat Reeve, Stephanie J. Loomis, Eija Nissilä, Thomas W. Soare, Tobias Rausch, Zhili Zheng, Pietro Della Briotta Parolo, Daniel Ben-Isvy, Elias Aho, Emilia Cesetti, Yoko Okunuki, Helen McLaughlin, Johanna Mäkelä, FinnGen, Mitja Kurki, , Heiko Runz
The paper identifies CFHR5 variants that reduce AMD risk by lowering FHR-5 levels and altering complement pathway activity.
Nature Communications · Jul 1, 2025Peer-reviewedGenetic & Genomic Medicine