t2pmhc: A Structure-Informed Graph Neural Network to predict TCR-pMHC Binding
Mark Polster, Josua Stadelmaier, Elias Ball, Jonas Scheid, Jens Bauer, Annika Nelde, Manfred Claassen, Marissa Lisa Dubbelaar, Juliane Sarah Walz, Sven Nahnsen
The paper introduces t2pmhc, a structure-informed graph neural network for predicting TCR-pMHC binding, showing improved generalization to unseen peptides compared to existing methods.
bioRxiv · Mar 6, 2026 · PreprintBioinformatics