Hematopoietic Stem and Progenitor Cell Aging is Initiated at Middle Age Through Decline in Local Insulin-Like Growth Factor 1 (IGF1)
Kira Young, Elizabeth Eudy, Rebecca Bell, Matthew Loberg, Tim Stearns, Lars Velten, Simon Haas, Jennifer Trowbridge
This study identifies declining IGF1 production in the bone marrow microenvironment as a driver of hematopoietic stem cell aging starting in middle age in mice.
bioRxiv · Jul 11, 2020 · PreprintCell Biology