Local ancestry modulates gene expression: shifting our understanding of genetic regulation and disease association within and across populations
Hung‐Hsin Chen, Yanwei Cai, Mariaelisa Graff, Wanying Zhu, Lauren E. Petty, Heather M. Highland, Rashedah Roshani, Hannah G. Polikowsky, Anna Lorenz, Elizabeth Frankel, Joshua M. Landman, Mohammad Yaser Anwar, Elyn E Franson, Jeffrey Haessler, Christy L. Avery, , Jennifer Elizabeth Below
The paper identifies ancestry-specific eQTL effects in Hispanic/Latino and African American populations, showing how local ancestry influences gene expression and disease risk.
medRxiv · Mar 18, 2026 · PreprintGenetic & Genomic Medicine